HUBUNGAN ANTARA PENGGUNAAN SEFALOSPORIN DENGAN PENINGKATAN APTT DAN PT PADA PASIEN KARDIOVASKULAR RAWAT INAP DI BANGSAL PENYAKIT DALAM DI RSUD Dr. M.YUNUS BENGKULU

Rahelia, Purba (2021) HUBUNGAN ANTARA PENGGUNAAN SEFALOSPORIN DENGAN PENINGKATAN APTT DAN PT PADA PASIEN KARDIOVASKULAR RAWAT INAP DI BANGSAL PENYAKIT DALAM DI RSUD Dr. M.YUNUS BENGKULU. Diploma thesis, Universitas 17 agustus 1945.

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Abstract

Background: One of the drugs used to treat cardiovascular disease is an anticoagulant, an anticoagulant is a type of drug used to lower blood pressure. Cephalosporins are the largest group of beta-lactam antibiotics. The mechanism of action of cephalosporins is to inhibit the synthesis of microbial cell walls. Cephalosporins are characterized by the presence of an N-methyl-thiotetrasol (NMTT) side chain that allows them to inhibit coagulation factors through the same mechanism as warfarin. The interaction between the two types of drugs can cause the concentration of warfarin anticoagulant to increase, causing an increase in the side effect of warfarin, namely bleeding. The interaction that occurs between warfarin and antibiotics is a pharmacokinetic interaction. Routine tests to assess coagulation activation are Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT), and fibrinogen levels, while routine hemostasis tests to assess fibrinolysis activation are D�dimer examination

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